A recent study suggests that people who discontinue new weight-loss injections like Wegovy and Mounjaro can put back on shed pounds at a significantly accelerated pace than those who end traditional lifestyle regimens.
Findings released in a major health publication points out that while overweight people often shed substantial amounts of their body weight while undergoing treatment, the mass is regained at an estimated rate of nearly a kilo each month upon discontinuation.
"Individuals using these treatments need to be cognizant of the risk of fast rebound weight gain when the therapy is stopped," cautioned researcher Dr. Susan Jebb.
That rate of recovery suggests a reversion to pre-treatment mass in about one and a half years.
Comparing Therapies
The research, which looked at dozens of trials involving over 9,000 of participants, contrasted the results of the injectable medications with conventional dieting.
Scientists emphasize that people who shed pounds through dieting generally experience a less rapid creep back—around 0.1 kg a month—post-intervention.
Explaining the Quick Regain
Doctors propose the mode of action of the jabs is key to understanding the accelerated weight return.
GLP-1 drugs mimic a natural hormone called glucagon-like peptide-1, which controls appetite.
"Artificially providing the hormone concentrations far above than the body's typical production could lead to the body to generate a reduced amount of its endogenous GLP-1, and could reduce responsiveness to its effects," said Dr. Adam Collins, a dietetics expert.
"Stopping of this medication results in hunger is no longer kept in check, making excessive eating far more likely."
A Lifelong Disease?
The NHS recommend the jabs for people with weight-linked medical conditions, accompanied by recommended lifestyle changes.
Professionals argue that, due to the significant potential of weight regain, the therapy is often ongoing.
This perspective is supported by drug manufacturers, who say that the results "highlight the persistent character of obesity," similar to managing diseases like diabetes.
Patient Testimonies
People who have come off the medication report a intense resurgence of cravings.
"It was like something flipping and I was suddenly extremely hungry," recalled a patient.
The struggle is worsened if individuals have not established permanent lifestyle or habit modifications during therapy.
Widespread Interest
Recent estimates suggest that millions of people in the UK have tried these injections in the past year, with interest remaining high.
- Use is greater among women compared to males.
- The middle-aged demographic shows the highest level of interest.
- A large proportion obtain the drugs through private healthcare rather than public health services.
In conclusion, experts stress that while GLP-1 drugs are powerful agents for weight loss, they are not a permanent cure and long-term success relies on ongoing lifestyle support.
